Cingal is protective

If you have knee pain, it maybe arthritis. If you know you have knee arthritis, Cingal is definitely an option for you. This post covers the technical aspects of what is in Cingal.

Cingal consists of Triamcinolone Hexacetonide, a ‘kinder’ yet potent steroid that is micronised in the manufacturing process, along with the Hyaluronic Acid. This creates a unique product, an all-in-one arthritis fighting injection. Many clinics may offer their own mix of a steroid type and another HA, but the steroid is likley to be less effective and the HA a weaker product.

Cinagl, a unique ‘next generation’ OA injection therapy, gives a safe and consistent delivery of both steroid and Hyaluronic Acid that complies with medical device regulations.

💉 One injection
🏨 One visit
💷 One standard cost
📈 92% response rate – 26 weeks
📉 72% pain reduction – 26 weeks

A very interesting scientific paper was published a couple of years ago, ‘increased chondroprotective effect of combining HA with a steroid…’ This paper directly tested Cingal and showed that it was just as effective as a steroid alone, but didn’t have the concerns that steroid has about damaging healthy cartilage. Cingal was proven to be a protective injection, improving the overall health of the knee, not just masking pain.

Key data points from this study:

Combining hyaluronic acid (HA) with Steroid, in the method in whihc is carried out with Cingal, offers several advantages over using steroid alone for osteoarthritis management:​

• Enhanced Chondrocyte Metabolic Activity: Cingal increases the metabolic activity of chondrocytes, which is essential for maintaining healthy cartilage function.
• Reduction in Catabolic Gene Expression: CINGAL effectively reduces the expression of catabolic genes such as MMP3, MMP13, and NOS2, which are associated with cartilage degradation. ​
• Decreased TNF-α Release: This combined therapy significantly lowers the release of TNF-α, a pro-inflammatory cytokine that contributes to inflammation and joint damage in osteoarthritis.
• Improved Cytoskeletal Integrity: Cingal enhances F-actin content in chondrocytes, indicating better cytoskeletal structure and potentially improved cellular resilience. ​
• Mitigation of Steroid Side Effects: While glucocorticoids alone may decrease sulfated glycosaminoglycan (sGAG) synthesis, combining them with HA (CINGAL) helps mitigate this adverse effect, supporting cartilage matrix preservation.

In summary, the CINGAL FORMULATION not only leverages the anti-inflammatory benefits of steroid but also incorporates the chondroprotective properties of hyaluronic acid, resulting in a more balanced and effective approach to osteoarthritis treatment.​

Read the full study here: Krems Institute Study

CINGAL FOR KNEE PAIN

Cingal offers patients with knee arthritis unmatched pain relief that starts within 24-48 hours of receiving the injection. The above paper scientifically demonstrates that the positive effects of rapid pain relief from steroid injections are not diminished with the Cingal formulation, but the potentially harmful effects associated with steroid injections on the chondral surface are.